It now seems certain that the amino acid sequence of any protein is determined by the sequence of bases in some region of a particular nucleic acid molecule.

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• Francis Crick:

  It is one of the more striking generalizations of biochemistry - which surprisingly is hardly ever

• Francis Crick:

  It has yet to be shown by direct biochemical methods, as opposed to the indirect genetic evidence m

• Francis Crick:

  If, for example, all the codons are triplets, then in addition to the correct reading of the messag

• Francis Crick:

  If the code does indeed have some logical foundation then it is legitimate to consider all the evid

• Francis Crick:

  If poly A is added to poly U, to form a double or triple helix, the combination is inactive.

• Francis Crick:

  The meaning of this observation is unclear, but it raises the unfortunate possibility of ambiguous

• Francis Crick:

  The balance of evidence both from the cell-free system and from the study of mutation, suggests tha

• Francis Crick:

  How is the base sequence, divided into codons? There is nothing in the backbone of the nucleic acid

• Francis Crick:

  For simplicity one can think of the + class as having one extra base at some point or other in the

• Francis Crick:

  Do codons overlap? In other words, as we read along the genetic message do we find a base which is