Even if it had not been possible to reproduce the disease in animals and consequently to verify the hypothesis, this simple observation would have been sufficient to demonstrate the way in which the disease was propagated.

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• Charles Jules Henry Nicole:

  From the practical point of view, the susceptibility to infection of the guinea pig proved to be th

• Charles Jules Henry Nicole:

  I demonstrated the characteristics of experimental fever. It appears after an incubation period whi

• Charles Jules Henry Nicole:

  I finally demonstrated that typhus infection is not hereditary in the louse.

• Charles Jules Henry Nicole:

  I was less successful in my attempts to effect preventive vaccination against typhus by using the v

• Charles Jules Henry Nicole:

  It did not seem likely that I was destined to undertake research on typhus.

• Charles Jules Henry Nicole:

  Just as the only reservoir for the typhus virus in nature is provided by man, so the only vector of

• Charles Jules Henry Nicole:

  Most of the doctors in the Tunisian administration, especially those in country districts, contract

• Charles Jules Henry Nicole:

  My first attempts to transmit typhus to laboratory animals, including the smaller species of monkey

• Charles Jules Henry Nicole:

  Of all the problems which were open to me for study, typhus was the most urgent and the most unexpl

• Charles Jules Henry Nicole:

  The discovery that I soon made that the guinea pig was also susceptible to infection made it possib