At the time when I was conducting my research there was no known method for taking the guinea pig's temperature. I demonstrated a technique which is now widely used.

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• Charles Jules Henry Nicole:

  Even if it had not been possible to reproduce the disease in animals and consequently to verify the

• Charles Jules Henry Nicole:

  From the practical point of view, the susceptibility to infection of the guinea pig proved to be th

• Charles Jules Henry Nicole:

  I demonstrated the characteristics of experimental fever. It appears after an incubation period whi

• Charles Jules Henry Nicole:

  I finally demonstrated that typhus infection is not hereditary in the louse.

• Charles Jules Henry Nicole:

  I was less successful in my attempts to effect preventive vaccination against typhus by using the v

• Charles Jules Henry Nicole:

  It did not seem likely that I was destined to undertake research on typhus.

• Charles Jules Henry Nicole:

  Just as the only reservoir for the typhus virus in nature is provided by man, so the only vector of

• Charles Jules Henry Nicole:

  Most of the doctors in the Tunisian administration, especially those in country districts, contract

• Charles Jules Henry Nicole:

  My first attempts to transmit typhus to laboratory animals, including the smaller species of monkey

• Charles Jules Henry Nicole:

  Of all the problems which were open to me for study, typhus was the most urgent and the most unexpl